白藜芦醇与关节炎的关系
2010-02-12以膝关节为主的风湿性关节炎，发病率会高达85%，也就是说几乎所有的人都会在其一生中饱受关节疼痛的困扰。长期以来对于风湿性关节炎的改善和预防的研究进展缓慢，但是却搞清楚了关节炎跟关节组织中的某些细胞因子（如TNF-α，LT-α等）的浓度过高有关。
膝关节炎还是肩周炎，吃了白藜芦醇后，疼痛可以得到缓解。这是为什么呢？
因为白藜芦醇可以将血清中的炎症因子TNF-α，LT-α等的浓度降低到正常值。
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u Usha R, et al. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells. Arterioscler Thromb Vasc Biol 1999; 19: 419-426. http://atvb.ahajournals.org/cgi/reprint/19/2/419 u Porath D, et al. Effects of resveratrol, piceatannol, tri-acetoxystilbene, and genistein on the inflammatory response of human peripheral blood leukocytes. Mol Nutr Food Res. 2005; 49: 431-42. u Elmali N, et al. Effects of Resveratrol in Inflammatory Arthritis. Inflammation 2007; 30: 1-6. u Bertelli AA, et al. Resveratrol inhibits TNF alpha-induced endothelial cell activation. Therapie. 2001; 56: 613-616. u Kowalski J, et al. Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1βand tumor necrosis factor-α genes in J774.2 macrophages. Pharmcolog reports 2005; 57: 390-394. u Moon SK., et al. Resveratrol Suppresses Tumor Necrosis Factor-a-Induced Fractalkine Expression in Endothelial Cells. Mol Pharmacol 2006; 70:112–119. |
而长期服用白藜芦醇，受损关节会得到修复，这跟白藜芦醇拥有抑制滑膜细胞异常增生（类风湿关节炎）、促进软骨细胞重新修复的能力有关，也就是说长期服用白藜芦醇是可以辅助让受损关节得到修复的。
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u Doissy P, et al. Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation. Cancer Res 2005; 65: 9943-9952. u Elmali N, et al. Effect of resveratrol in experimental osteoarthritis in rabbits. Inflammation Res. 2005; 54: 158-162. u Tang LL, et al. Inhibitory effect of resveratrol on the proliferation of synoviocytes in rheumatoid arthritis and its mechanism in vitro. J Cent South Univ（Med Sci）2006；31：528-533. |
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