白藜芦醇与肿瘤的关系
2010-02-12自从1992年在葡萄酒中发现白藜芦醇以来，对它的研究就开始升级。虽然1993年就有报导白藜芦醇对肿瘤相关的激酶有抑制活性，对小鼠白血病细胞的生长有抑制作用，但没引起重视。
到了1997年，Jang等人报导了白藜芦醇在肿瘤发展的三个阶段（initiation，promotion，progression）均有抗肿瘤活性的系统性研究后，才引起广泛注意，从此这方面的研究一发不可收，势如潮水。到2009年6月底止，大概有一万五千篇关于白藜芦醇抗肿瘤的学术论文已经发表。研究证明，白藜芦醇拥有多重作用来控制、抑制和消灭肿瘤细胞，包括诱导肿瘤细胞凋亡，抑制基因突变，改变基因表达谱，调节免疫体系，抑制新生血管生成等作用。
下面列举10个有代表性的论文。
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u Jang M，Cai L, et a1．Cancer chemopreventive activity of resveratrol, a natural product derived from grapes．Science 1997；275(5297): 218-220. u Clement MV, et al. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor. Blood 1998; 92: 996-1002. u Kimura Y & Okuda H. Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J. Nutr. 2001; 131: 1844-1849. u Brakenhielm E, et al. Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes. The FASEB J 2001; 15: 1798-1800. u Gao XH, et al. Disparate in vitro and in vivo anti-leukemic effects of resveratrol, a natural polyphenolic compound found in grapes. J. Nutr. 2002; 132: 2076-2081. u Tseng SH, et al. Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats. Clinical Cancer Research 2004; 10: 2190-2202. u Sunita B. et al. Resveratrol-induced gene expression profiles in human prostate cancer cells. Cancer Epidemiol Biomarkers Prev 2005; 14: 596–604. u Kotha A, et al. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Mol Cancer Ther 2006; 5(3): 621-629. u Su JL, et al. Forkhead Proteins Are Critical for Bone Morphogenetic Protein-2 Regulation and Anti-tumor Activity of Resveratrol J. Biol. Chem. 2007; 282: 19385 - 19398. u Byun HS, et al. Caspase-8 has an essential role in resveratrol-induced apoptosis of rheumatoid fibroblast-like synoviocytes. Rheumatology 2008; 47: 301-308. |
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